Abstract: Objective: To investigate the effect of methylprednisolone on thoracic spinal stenosis symptom.Methods: 82 patients adopt of simply posterior thoracic vertebral canal decompression.8 cases occurred acute spinal shock symptom after（2～4 h） surgical decompression.Considering this kind of symptom is spinal cord ischemic reperfusion（IR） injury.All cases infusion methylprednisolone 1 000 mg before decompression in 30 min.After operation,77 cases were infused methylprednisolone extenuation day by day and 3 cases were spinal cord IR injury;5 cases of spinal cord IR injury were treated with stoss and maintenance dose of methylprednisolone therapy.Results: No death was noted,and 1 case occurred stress ulcer.Among cases treated with methylprednisolone extenuation therapy,74 cases recovered well;3 cases of spinal cord IR injury motor function recovered slowly.After 1 year follow-up,1 case completely recovered and the other 2 cases were not well.5 cases treated with stoss and maintenance dose of methylprednisolone therapy,4 cases motor function remarkably recovered,1 case recovered slowly.After 1 year follow-up,5 cases completely recovered.Conclusion: Methylprednisolone has significantly effect on treatment of thoracic stenosis symptom in extenuation spinal cord swelling,inhibit vasoactive substance,stabilize cellular and lysosomal membrane.