Abstract: Objective: To study destructive damage of bile duct of hepatic artery embolization in treatment of hepatic cavernous haemangioma. Methods: 4 cases of destructive biliary damage in asymptomatic hepatic haemangioma resulting from hepatic artery embolization since 1989 were reported. To study the pathogenesis of bile duct damage, the hepatic artery was injected with ethanol so as to evaluate liver damage in experiment rat. Results: All cases were found to have destructive damage of intra and extrahepatic bile duct at the hilum with biliary hepatocirrhosis, 3 cases intrahepatic bile duct jejunal anastomosis and bile duct stent were performed. The experimental result revealed necrosis of the liver, especially around the portal tract area. Conclusion: Hepatic arterial embolization therapy of hepatic haemangioma may be resulted into severe biliary damage and its indiscriminate use should be prohibited.