Abstract: Objective To evaluate the effect of insulin intensive therapy combined with pioglitazone,an insulin sensitizer,on newly diagnosed type 2 diabetes mellitus（T2DM）. Methods Sixty patients with newly diagnosed T2DM were treated with insulin intensive therapy for 4 weeks.Then,the patients were randomly divided into group A receiving insulin intensive therapy combined with pioglitazone（n=32） and group B receiving simple insulin intensive therapy group（n=28）.Eight weeks later,levels of glucose tolerance（OGT）,insulin,glycosylated hemoglobin A1c（HbA1c）,BP,lipid,and uric acid were measured.HOMA-IAI and HOMA-IR were calculated. Results The levels of FBG,HbA1c,TG,cholesterol,LDL-C,SBP,and DBP decreased dramatically 12 weeks after treatment.FBG,HbA1c,LDL-C and cholesterol were significantly improved in group A compared with group B.The HOMA-IAI and HOMA-IR were notably improved in group A compared with group B. Conclusion Insulin intensive therapy combined with pioglitazone improves T2DM by decreasing insulin tolerance,protecting the function islet βcells,and controlling blood glucose.