Abstract: Objective: to explore the effect of early intervention on infant intellectual and mental development. Methods: 41 normal infants were assigned to intervention group received the early intervention from birth.The early intervention included evaluation of physical and mental development, and training direction, which were given once a month in the first year and once two months in the second year.The normal control group consisted 53 infants.Toddler temperament scale （TTS） was adopted to assess temperament.All children aged 1.5 years were assessed by intelligence test of Child Development Center of China （CD-CC）. Results: intelligence development; mental development index （MDI） in intervention group show 10 scores higher than control group （t =2.88,P＜0.01）, 22 children （53.7%）in intervention group show MDI≥ 120（excellent and superexcellent）, while 14 in control group.There is no difference among the distribution of temperament types between the two groups.There were significant difference of some temperamental dimensions such as ryhthmicity mood distraction. Conclusion: Early intervention can promote intellectual development of children, and make them have higher physiological rhythmicity, more positive mood, and less distraction.