Abstract: Objective: To explore a new method aimed at effectively controlling the scar hypertrophy. Methods: 10 patients undergoing split-thickness skin grafting were randomly selected for the study.Each skin donor site wound received two treatments, one area grafted with microskin （M group） and another adjacent area covered with vaseline gauze （V group）.The scores of pruritus of scar was evaluated.Skin biopsies were also collected, routine pathological examination and special staining for collagen fiber were performed. Results: Satisfying improvements were achieved in M group compared with V group in the color, texture, thickness and scores of pruritus of scar, and the distribution of capillary and collagen fiber in M group were also better than V group. Conclusion: Microskin grafting, significantly decreasing scar hypertrophy, could be applied not only to the split-thickness skin donor site, but also to deep partial-thickness burn wound.