麻醉时间或低血压对七氟醚MAC影响的实验研究

Influence of duration of anesthesia or hemorrhagic hypotention on MAC of sevoflurane in rabbits

摘要: 目的: 观察麻醉时间或低血压对七氟醚MAC影响。方法: 20只新西兰兔随机分成正常血压组(Ⅰ组)、失血性低血压组(Ⅱ组),每组10例。采用夹尾实验法测定两组动物七氟醚MAC,每小时测定1次,持续4h。采用经颈总动脉放血法将兔平均动脉压降至基础值的2/3。结果: 麻醉时间对正常血压和低血压兔七氟醚MAC均无明显影响;失血性低血压可以降低七氟醚MAC,降低幅度为(27± 5)%。结论: 麻醉时间基本不影响七氟醚MAC,低血压可以降低七氟醚MAC。

Abstract: Objective: To observe the influence of duration of ansthesia or hemorrhagic hypotention on MAC of sevoflurane in rabbits. Methods: 20 New Zealand rabbits were randomly divided into normotensive group （group Ⅰ）, hemorrhagic hypotention group （group Ⅱ）. MAC of sevoflurane was determined once per hour with tail clamp in each group, which last 4 hour. Mean arterial pressure （MAP） of hemorrhage group was dropped to two third of baseline through carotid artery bloodletting. Results: MAC of sevoflurane in both group wasn′t effected by duration of anesthesia. Hemorrhagic hypotention might decrease MAC of sevoflurane by （27±5）%. Conclusion: Duration of anesthesia hardly works on MAC of sevoflurane, but hemorrhagic hypotention may decrease it.