Abstract: Objective: To study the related dangerous factors of acute cerebral apoplexy （ACA） combined with upper gastrointestinal hemorrhage （UGH）. Methods: By investigating the clinical data of 391 cases of acute cerebral apoplexy in hospital, we retrospectively analyze such aspects as age, the type of cerebral apoplexy, the position of pathological changes, the degree of the illness, the death rate of illness and the incidence rate of upper gastrointestinal hemorrhage. Results: There are 62（15.9%） cases of ACA combined with UGH in 391 cases of ACA. The incidence rate increases with the growing age, and the percentage is 51.6% when the age is ≥ 70 years. The rate of bleeding cerebral apoplexy is obviously larger than that of ischemia one（P＜0.01）. The rate of thalamus bleeding, apoplexy entering cerebral ventricle is larger than that of bleeding at other positions （P＜0.05,P＜0.01）.The rate of cerebral infarction in large area, frequent cerebral infarction is larger than that of other ones （P＜0.05,P＜0.010）. The rate of the serious cerbral apoplexy is larger than that of the slight one or medium-degree one（P＜0.01）. There is a very significant difference （P＜0.01）between the death rate of cerebral apoplexy combined with UGH （24.2%） and that of cerebral apoplexy combined with no UGH （3.6%）. Conclusion: ACA combined with UGH is correlated with the type of cerebral apoplexy, the position of pathological changes and the degree of the illness.