降钙素基因相关肽在诱发实验犬过敏性支气管哮喘中的变化

The change of calcitonin gene-related peptide in experimental canine allergic bronchial asthma

摘要: 目的：观察降钙素基因相关肽（CGRP）在过敏性支气管哮喘发病机制中的作用。方法：用猪蛔虫蛋白激发实验犬过敏性支气管哮喘，RIA法检测血浆及支气管肺泡灌洗液（BALF）中CGRP。结果：血浆中CGRP在激发哮喘后1h显著下降，BALF中CGRP在激发后1h和2h显著低于激发前和激发后即刻的水平。这种变化趋势可能与肺组织中CGRP受体与CGRP结合率的升高有关。结论：研究提示神经原性炎症反应参与支气管哮喘发病机制。

Abstract: Objective:To observe the effect of CGRP in the pathogenefic mechanism of bronchial asthma.Methods:The experimental canine allergic bronchial asthma was induced with Ascaris ovum extract antigen. The CGRP in dog plasma and BALF was measured by radioimmunoassy. Results:The plasma CGRP decreased significantly 1 hour after asthma was evoked, and the CGRP in BALF also significantly decreased at 1 and 2 hours compared with that before evocation or immediately after evocation. These tendencies of change were probably related to the increase of the combination rate of CGRP receptor.Conclusion:The observation suggests that the neurogenic inflammatory response may be involved in the pathogenesis of bronchial asthma.