Abstract: Objective: To explore its correlation with the knee prosthesis design through the study in the morphology of the knee by using computer-aided design （CAD）. Methods: The CT imaging data of 6 cadaver knees were obtained. Through CAD software, the 3-D solid models, were reconstructed and measured. To test the results obtained from CAD models, we measured the cadaver knees manully, realizing errors between two methods and analyzing causes. Results: The geometric parameters from CAD measurement were smaller than those from the manual. The mean errors werebetween 1.33 mm and 2.64 mm in radius parameters, and between 0.73mm and 1.31 mm in linear parameters. Conclusion: It was facility to the related analysis and research of the morphology of the knee by using computer-aided design （CAD）.