Abstract: Objective: To observe the change of neural stem cells（NSCs） in striatuma during the developing human fetal brain at different fetal stage. Methods: 60 cases of embryoes at gestational 16w～28w age and by induction of labor with water bag were collected for determining distribution,shapes,growth modes and the number of NSCs in striatuma with hybridization in situ under light microscope. Results: NSCs expressing Nestin mRNA existed in striatuma from human fetal brain at different stage and had obvious crowd distribution,most NSCs existed in a single growth mode,volumes of NSCs differ greatly,large or small.NSCs existed in striatuma of different fetal age included round cells,oval cells and astrocytes,there were NSCs enations from 0 to 3.Nucli submitted round and oval shapes,each having nucleoli from 1 to 4.NSCs had rarefaction chromatin,NSCs in striatuma gradually decreased with increase of age. Conclusion: NSCs exist in striatuma from different gestational stage,Nestin mRNA may be a reliable marker for determining NSCs.