Abstract: The effect of Halcinonide in the treatment of 179 cases of psoriasis has been observated in this paper.As the result,126 cases cured,the cure rate being 70.4%;in 170 cases it was quite effective,the rate of effectiveness being 95%.In 37 cases there was side effect of the skin,the side effect rate being 29.7%.47 patients had recurrences（36.4%）.Comparing Halcinonide with Fluocinonide,Beclomethason and Triamcinolone in the treatment of the same patients,it was found that Halcinonide was more effective than others.Finally,the mechanism of Halcinonide was reviewed.