近5年铜绿假单胞菌临床分布及耐药现状
Clinical distribution of Pseudomonas aeruginosa and its drug resistance status in the past 5 years
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摘要: 目的 了解2006-2010年我院铜绿假单胞菌临床分布及耐药情况, 为临床合理选用抗生素提供依据。 方法 细菌鉴定采用VITEK微生物分析仪, 药物敏感性试验采用BIOMIC药敏测定仪, 耐药性分析采用WHONET5.4软件。 结果 5年来铜绿假单胞菌分离率占第一位, 其中在痰标本中检出最高, 其次是尿液标本, 检出率分别为72.9%和7.6%;铜绿假单胞菌对头孢吡肟敏感性最好, 耐药率最低 (11.4%-34.3%) , 其次是头孢他啶 (13.9%-37.7%) 、氨曲南 (17.5%-66.7%) 和阿米卡星 (13.3%-46.6%) 。 结论 痰标本中分离出的铜绿假单胞菌对多种抗生素的耐药率高于尿标本, 连续5年该菌对亚胺培南的耐药率有增高趋势。Abstract: Objective To study the distribution of Pseudomonas aeruginosa and its drug resistance in our hospital from 2006 to 2010 in order to provided the scientific evidence for rational use of antibiotics. Methods Bacteria were identified with the VITEK system and antibiotic sensitivity was tested by BIOMIC.Drug resistance of Pseudomonas aeruginosa was analyzed using the WHONET 5.4 software. Results The most dominant organism was Pseudomonas aeruginosa with a detection rate of 72.9% in sputum and 7.6% in urine from 2006 to 2010.The sensitivity of Pseudomonas aeruginosa to FEP was the lowest（11.4%-34.3%）,followed by CAZ（13.9%-37.7%）,ATM（17.5%-66.7%）,and AMK（13.3%-46.6%）. Conclusion The drug resistance of Pseudomonas aeruginosa isolated from sputum is higher than that isolated from urine with an increase tendency to IPM.
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