Abstract: Objective:The aim of this study was to observe the changes of the hemodynamics, blood gluose, glucagon and the levels of plasma insulin and cortisol when Propofol was used for endotracheal intubation. Methods:Eighteen patients were randomly divided into two groups, sodium pentothal （SP） group and Propofol （P） group. These parameters were investigated respectively before anaesthesia and, 1,5,10 min after endotracheal intubation. Results:The level of plasma insulin remained stable during endotracheal intubation. However, blood glucagon, cortisol and glucose increased sinificantly in SP group, as compared with those before anaesthesia, but there was no sinificant change in P group. There revealed marked difference, between two groups （P＜0.05）. In addition, the heart rate and the blood presure were much lower in P group than in SP group （P＜0.05）. Conclusion:The stress reponse to endotracheal intubation may be effectively diminished by Propofol combined with Diazepam and Fentanyl.