Abstract: Objective: To observe the effect of salivary adenoid cystic carcinoma cells（SACC-83） on the growth of Schwann cells deriving from the sciatic nerve in vitro co-culture. Methods: Sciatic nerve was co-cultured with SACC-83,tongue cancer cells,and fibroblasts,respectively.Slides of the cultured cells were prepared and stained with immunohistochemistry. Results: The SACC-83 promoted the growth of Schwann cells.The Schwann cells were stained brown with anti-S-100 protein,but fibroblasts were not stained. Conclusion: SACC-83 can promote the growth of Schwann cells,which may be one of the mechanisms underlying the perineural invasion of SACC-83.