Abstract: Objective To study the incidence of major cardiovascular events by observing the clinical outcome of the first-generation drug-eluting stents（DES） 5 years after implantation. Methods The incidence of major cardiovascular events,including recurrent angina pectoris and revascularization of non-target vessels,was investigated in 156 patients who underwent DES implantation in our centre from January to December 2004. Results The follow-up time of the 156 patients who underwent DES implantation was 5.21±0.32 years.Of the 32 patients（21%） who developed major cardiovascular events,5 died of cardiac diseases（3.2%）.Lesion and revascularization of target blood vessels were observed in 19 patients（12.2%）.Recurrent non-fatal cardiac infarction and angina pectoris occurred in 8 patients（5.1%） and 43 patients（27.6%）,respectively.Revascularization in other blood vessels was observed in 6 patients who received CABG treatment.Cerebral hemorrhage and infection were found,respectively,in 1 patient.One patient died of tumor.Logistic regression analysis showed that the clopidogrel treatment time（P=0.016,OR=1.1,95%CI=1.018-1.188） was an independent risk factor for major cardiovascular events（P=0.039,OR=3.35,95%CI:1.06-10.55）. Conclusion The incidence of major cardiovascular events increased in patients with lesions of multiple blood vessels,which is not reduced after long-term clopidogrel therapy.