Abstract: Objective To study the changes of different urine special proteins b2-MG,mAlb,IgG,α1-MG in elderly diabetic mellitus（DM） patients with kidney injuryMethods A total of 284 elderly DM patients were divided into 3 groups according to the grade of diabetic nephropathy and the time they suffered from the disease,60 healthy old persons served a control group.Levels of urine special proteins including b2-MG,mAlb,IgG,α1-M in 284 elderly patients and 60 healthy controls were measured.The clinical indexes for the impaired kidney function were analyzedResults The levels of urine b2-MG,mAlb,IgG,and α1-MG were significantly higher in DM patients than in controls（P＜0.01）,and increased with the progress and prolongation of nephropathy（P＜0.05）Conclusion The levels of b2-MG,mAlb,IgG,and α1-MG are the indications of impaired kidney function in elderly DM patients and are of certain value for judging the severity and site of impaired kidney function.