免疫肠内营养支持对胃肠道肿瘤患者术后的作用

Effects of postoperative immune enteral nutrient on immune function in patients with gastrointestinal cancer

摘要: 目的: 观察免疫肠内营养制剂茚沛(IMPACT)对胃肠道肿瘤患者手术后的免疫调节作用。方法: 胃肠道肿瘤患者随机分为IMPACT组和能全素(NUTRISON)组,在手术后进行肠内营养支持10d,肠内营养用量为10 4 6kJ (2 5kcal)/(kg·d),术前和术后11d测定血浆白蛋白、IgA、IgG、IgM、淋巴细胞计数、T淋巴细胞亚群分类。结果: 术后第11d,IMPACT组血浆白蛋白升高(P<0.0 5),免疫功能指标较NUTRISON组有明显增强。结论: 免疫肠内营养支持能更好地改善胃肠道肿瘤患者术后机体的免疫功能。

Abstract: Objective: To elucidate the effect of postoperative immune enteral nutrient on immune function of gastrointestinal（GI） cancer patients.Methods: Sixty patients with GI cancer were divided into two groups: IMPACT group,NUTRISON group They were all given each enteral nutrition which provides 104 6 kJ （25 kcal）/（kg.d） for 10.days after digestive tract surgery plasma protein,IgA,IgG,IgM,total lymphocyte count,peripheral blood T lymphocyte subset were measured in the day before operation and on the 11 th postoperative day.Results: In IMPACT group,plasma protein were increased （P＜0.005） and the indexes of immune function were improved significantly.Conclusion: enteral nutrient IMPACT helps to ameliorate the immune function of postoprative GI cancer patients better than NUTRISON.