朊蛋白PrPc及磷酸化Akt在胃癌中共表达及其临床意义

Co-expression of PrPc and p-Akt in gastric cancer and its clinical significance

摘要: 目的研究朊蛋白PrPc与磷酸化Akt(p-Akt)在胃癌组织中的表达及其临床意义。方法采用免疫组织化学方法对85例胃癌及癌旁组织中的PrPc及p-Akt蛋白表达进行检测。结果 85例胃癌组织中PrPc及p-Akt的阳性表达率分别为82.4%及88.2%,均较癌旁组织明显增高(P<0.05)。PrPc及p-Akt在胃癌组织中的表达存在明显相关性(r=0.514,P<0.05),且均随分化程度下降而表达强度上升。结论 PrPc及p-Akt在胃癌组织中协同表达,p-Akt有可能在PrPc介导的胃癌恶性表型中发挥作用。

Abstract: Objective To study the expression of PrPc and p-Akt in gastric cancer tissue and its clinical significance. Methods Expressions of PrPc and p-Akt in gastric cancer tissue and its adjacent tissue were detected by immunohistochemistry. Results The positive expression rate of PrPc and p-Akt was 82.4%（66/85） and 88.2%（75/85）,respectively,in 85 gastric cancer patients,which was significantly higher than that in its adjacent tissue（r=0.514,P＜0.05）.The expression levels of PrPc and p-Akt were significantly correlated with the down-regulated differentiation of gastric cancer cells and up-regulated expression of PrPc and p-Akt in gastric cancer tissue（P＜0.05）. Conclusion PrPc and p-Akt are synergistically expressed in gastric cancer tissue,and p-Akt may play a role in PrPc-induced malignant phenotype of gastric cancer.