Abstract: Objective To investigate the therapeutic effect of high pressure balloon catheter dilation on multi-segment benign ureterostenosis. Methods High pressure balloon catheter dilation was performed for 15 patients（11 males and 4 females, at a mean age of 40 years） with multi-segment benign ureterostenosis. Of these patients, 13 had unilateral and 2 had bilateral multi-segment benign ureterostenosis. Scar-caused, congenital and inflammatory strictures were found after operation. Thirteen and 4 strictures were treated with retrograde dilation through the urethra and percutaneous renal pelvis puncture, respectively. Results All the operations were successful. The 15 patients were followed up. Ureterostenosis was cured in 9 patients, while good and poor outcome was achieved in 5 and 3 patients, respectively, with a total effective rate of 82.4%. Conclusion High pressure balloon catheter dilation is an safe and effective procedure for patients with multi-segment benign ureterostenosis.