Abstract: Objective To study the effect of intravascular stenting in patients with multiple coronary artery stenosis. Methods A total of 226 patients with multiple coronary artery stenosis undergoing intravascular stenting in March 1998-March 2008 were divided into group A（n=183） and group B（n=43）,and retrospectively analyzed. Results A total of 270 stents were implanted into 226 patients.The mean diameter of stenosis was 87% ±13% before operation and 3% ±10% after operation in group A,while it was 86%±14% before operation and 3%±5% after operation in group B.There was no difference in vascular lumen and related complications between the two groups after operation（P＞0.05）. Conclusion Coronary artery stenting can achieve rather good clinical results in multiple coronary artery stenosis.