2132例不同人群血清中SARS-CoV抗体水平调查

宋淑珍; 贾兴旺; 田亚平

2132例不同人群血清中SARS-CoV抗体水平调查

Studies on the serum SARS-CoV（IgG）antibody level in 2132 cases of different population

摘要

摘要: 目的: 探讨SARS-CoV（IgG）抗体检测辅助诊断非典型肺炎的临床应用价值。方法:采用ELISA方法及蛋白芯片法对2132例不同人群的血液标本检测SARS-CoV（IgG）抗体，分析SARS康复者与其它疾病患者和正常人群抗体水平的差异。结果:用ELISA方法测定SARS康复者、肾病、恶性肿瘤、肺部疾病和糖尿病患者、其它疾病的SARS-CoV（IgG）抗体阳性率分别为75.6%（118/156）、29.3%（22/75）、22.3%（19/85）、22.7%（10/44）、13.6% （8/59），500例健康查体人员全部为阴性，500例密切接触人员也为阴性。蛋白芯片方法测定SARS康复者的抗体阳性率为86%，对62例ELISA方法阳性的非SARS患者测定，仅发现4例阳性。结论: SARS-CoV（IgG）抗体可辅助回顾性诊断是否有SARS-CoV的感染。与ELISA方法相比，蛋白芯片方法具有更高的特异性和灵敏度。

Abstract: Objective:to evaluate the clinical significance of the measurement of serum SARS-CoV（IgG）antibody.Methods:The serum SARS-CoV antibody have been measured in different population by both ELISA method and biochips technique，to analyze the difference between SARS and other diseaseas.Results:The positive rate of SARS-CoV（IgG）in convalescent SARS cases，nephropathy，cancer，pulmonary diseases，diabetes and other diseases were 75.6%（118/156）、29.3%（22/75）、22.3% （19/85）、22.7%（10/44）、13.6%（8/59） respectively，both 500healthy population and 500close contact medical staff in xiao tang shan hospital were negative ，which were measured by ELISA method.The biochips results indicated that convalescent - SARS cases have a positive rate of 86% and only 4 cases have positive SARS-CoV antibody in 62cases which have positive results by ELISA.Conclusion:Measurement of SARS-CoV antibody is a helpful marker to diagnosis recent SARS-associated coronavirus （SARS-CoV） infection.Biochips technique has better specificity and sensitivity than ELISA.

HTML全文

参考文献(0)

施引文献

资源附件(0)