慢性乙型肝炎患者干扰素治疗后外周血树突状细胞的变化
Changes of peripheral dendritic cells in chronic hepatitis B patients treated with CINF
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摘要: 目的: 动态观察慢性乙型肝炎患者复合α干扰素(consensus interferon,C IFN)治疗过程中DC细胞亚群的变化。方法: 采用流式细胞分析技术检测23例慢性乙型肝炎患者C IFN治疗过程中外周血树突状细胞(den-dritic cell,DCs)亚群百分比及数量,同时检测乙型肝炎病毒血清学标志和血清HBVDNA,以及肝功、肾功、血常规。结果: 经C IFN治疗后,患者的应答率为43.5%。慢性乙型肝炎患者外周血MDC及PDC的百分比和绝对数显著减少(P<0.05),且有效组和无效组的MDC及PDC的百分比和绝对数在同一时间点无明显差别。动态观察C IFN治疗过程中血清HBVDNA载量与MDC、PDC绝对数的关系,未发现明确的相关性(P>0.05)。结论: 慢性乙型肝炎患者经CIFN治疗后,部分患者可以获得持续性病毒学及生化学应答,外周血MDC及PDC的百分比和绝对数明显下降。Abstract: Objectives: To observe the changes of peripheral dendritic cells subsets consecutively in patients with chronic hepatitis B during Consensus Interferon（CIFN） treatment.Methods: Twenty-three patients with chronic hepatitis B were treated with CIFN for 24 weeks and followed up for another 24 weeks.After CIFN withdrawal,During CIFN treatment peripheral dendritic cell subsets were measured.Results: After CIFN treatment,43.5% patients obtained virological and biochemical responses.The percentage and absolute number of peripheral type I and Ⅱdendritic cells decreased greatly（All P＜0.05）.Conclusions:Consistent virological and biochemical response can be obtained in some patients with chronic hepatitis B virus infection after CIFN treatment,and the percentage and number of peripheral type I and Ⅱdendritic cells are greatly decreased too.
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