Abstract: The renal pathological sections （by computer imaging quantitative analysis） and clinical manifestations in patients with minimal change disease （MCD）, IgM nephropathy （IgMN） and non-IgA,-IgM mesangial proliferative glomerulonephritis（MsPGN） were analysed. The results showed that IgMN and MsPGN with nephrotic syndrome were 11.39% in primary glomerulonephritis. The prevalence of IgMN（48.89%） was the highest in thee kinds of renal disease. There were higher proportions of temporary renal dysfunction and dependance of corticoids in patients with MsPGN, but distinct hematuria occurred in patients with IgMN and MsPGN. The results of imaging quantitative analysis in renal pathological sections showed that the count of mesangial cells and area of mesangial matrix and renal interstititium in patients with IgMN and MsPGN were increased significantly than in patients with MCD（P ＜0.01） and the area of mesangial matrix in patients with IgMN（P ＜0.01）;The more inceased area of renal interstitium was, the more hypertension, hematuria, temporary renal dysunction and dependance of corticoids were. It indicates that IgMN is a benign renal disease with specific clinical feature and renal morphologic change, but MsPGN is a relatively serious disease.