Abstract: Objective:To Evaluate the relationship between the expression of multidrug resistance protein or bcl-2 protein and prognosis in newly diagnosed AL patients. Methods: Immunochemistry and FCM methods were used to examine the expression of multidrug resistance protein and bcl-2 protein in 29 newly diagnosed acute leukemia （AL） patients. Results: The positive rate of multidrug resistance protein and bcl-2 protein expression in newly diagnosed AL was 37.9% and 83% respectively. The difference of the first complete remission rate in bcl-2 negative and in bcl-2 positive patients was not significant （P＞0.05）,but the difference of the first complete remission rate in multidrug resistance protein negative and in multidrug resistance protein positive patients was significant （P＜0.05）.There was no relationship between bcl-2 and multidrug resistance protein. Conclusions: Multidrug resistance protein is a good indicator to forecast prognosis in newly diagnosis leukemia patients.