Abstract: Objective: To observe effect of the gene polymorphism of low density lipoprotein receptor on the efficacies of the lipids regulation of micronized fenobrite.Methods: Fifty two patients with hyperlipidemia （serum total cholesterol level exceeded or equal to 5.20 mmol/L, and/or triglyceride level was in the range 2.00-5.65 mmol/L） were randomly allocated into Fenobrite group and paacebo group （30 and 22 cases, respectively）. The low density lipoprotein receptor HincⅡ polymorphism were measured by polymerase chain reaction technology.Results: Comparing the efficacies of regulation of lipids of Fenobrite and placebo among the subgroups with H1H1, H1H2, or H2H2 genotype of low density lipoprotein receptor HincⅡ polymorphism, we did not find that the efficacy rates （10% fall in total cholesterol and in low density lipoprotein cholesterol, 20% fall in triglyceride, and increase more than 0.1 mmol/L in high density lipoprotein cholesterol, respectively） of patients with H1H2 or H2H2 genotypes were significantly different among the different genotytes of Fenobrite and control groups. The lowered ranges of total cholesterol, low density lipoprotein cholesterol, and triglyceride were neither marked different among the patients with H1H1, H1H2, and H2H2 genotypes, average reduction percent of total cholesterol were in sequence 30.3, 30.2, and 33.4% （P＞0.05）, low density lipoprotein cholesterol were 28.0, 29.1, and 31.8% （P＞0.05）, triglyceride were 55.2, 53.9, and 53.62% （P＞0.05）. Responsiveness were less different between patients with h1 allele and h2 allele in Fenobrite and placebo group. Conclusion: The result of present study suggested that low density lipoprotein receptor HincⅡ alleles do not took part in the key processes of the cholesterol or triglyceride regulation of Fenobrite.