Abstract: Objective To analyze the effect of ultrasound-guided percutaneous microwave ablation（coagulation） therapy（PMCT） on superficial hepatocellular carcinoma（HCC） and its complications. Methods Eighty-five superficial HCC patients（103 superficial HCC close to the abdominal wall） underwent PMCT.The diameter of HCC was 0.7-8.1cm（4.1±2.3cm）.The microwave power was adjusted during the treatment of patients according to their temperature.The patients were followed up for 3-28 months（11.2±4.5 months） during which the inactivated HCC,hepatic function and complications were observed. Results The complete necrosis rate of HCC was 76.6% and 100%,respectively,after 1 and 2 times of ablation.Local recurrence occurred in 8 foci with a recurrence rate of 7.7%.Of the patients,46 had fever,59 had local pain,and 3 had abdominal distension,nausea and vomiting,shoulder pain,and 1 had skin burning.No operation-related complication occurred. Conclusion PMCT is an effective and safe modality for superficial HCC.