大麻素Ⅱ型受体在结节病、环状肉芽肿中的组织分布

Distribution of cannabinoid receptor 2 expression in sarcoidosis and granuloma annulare tissues

摘要: 目的: 研究大麻Ⅱ型受体(CB2)在人正常皮肤及结节病、环状肉芽肿的组织分布。方法: 用兔抗人CB2受体抗体做免疫组化,检测人皮肤及结节病、环状肉芽肿的组织CB2受体表达分布情况。结果: CB2受体在人皮肤及结节病、环状肉芽肿均有表达分布,且结节病、环状肉芽肿的CB2受体过度表达。结论: 大麻素受体CB2的表达与皮肤结节病、环状肉芽肿关系密切。

Abstract: Objective: To investigate the distribution of cannabinoid receptor 2（CB2） expressions in human normal skin,sarcoidosis,and granuloma annulare tissues. Methods: The distribution of CB2 expressions in human normal skin,sarcoidosis,and granuloma annulare tissues was detected with immunohistochemical staining. Results: The distribution of CB2 expression was observed in human skin,sarcoidosis and granuloma annulare tissues.CB2 was over expressed both in sarcoidosis tissue and in granuloma annulare tissue. Conclusion: CB2 expression of CB2 is closely related with sarcoidosis and granuloma annulare.