Abstract: Objective To observe the effect of simvastatin and captopril on heart function and hemodynamics of diabetic rats. Methods Diabetic rats were randomly divided into control group,simvastatin group,captopril group,and simvastatin + captopril group.Rats in control group were given placebo,rats in simvastatin group received simvastatin（15 mg/kg/d）,rats in captopril group were given captopril（2 mg/kg）,and rats in captopril + simvastatin group received captopril（15 mg/kg/d） and simvastatin（2 mg/kg） for 4 weeks.Then,parameters of rat hemodynamics and heart function were measured. Results No significant difference was observed in LVEDP between simvastatin + captopril and control groups.The maxium increased speed of LVEDP was higher while the maxium reduced speed was lower in simvastatin + captopril group than in control group（P＜0.05）. Conclusion Combined captopril and simvastatin can significantly improve the heart function of diabeteic rats.