Abstract: Objective: To make an inquiry into the probable risk factors for antibiotic multi-resistance bacterial infection in patients with liver cirrhosis by case-control study. Metheds:18 liver cirrhosis patients with infection of antibiotic multi-resistant bacteria were compared with 91 control cases whose infection were caused by antibiotic sensitive bacteria. Factors such as age, gender, duration of hospital stay, steroid use, intubatton, nosocomial infection, duration of antibiotic treatment before infection, biochemical index of hepatic function were investigated in all patients. Results: A univariable analysis showed that nosocomial infection, intubatton, serum total bilirubin and duration of antibiotic treatment before infection were the risk factors for multi-antibiotic resistance. By multivariable logistic regression analysis, We found only nosocomial infection and duration of antibiotic treatment before infection were the risk factors for antibiotic multi-resistance bacterial infection. Conclusion: Efforts should be emphasized on controlling nosocomial infection and judicious using of antibiotics, which may decrease the risk of antibiotic multi-resistant bacterial infection in patients with liver cirrhosis.