肌酸激酶同工酶质量与活性测定在心血管疾病中的应用
The measurement of creatine kinase isoenzymes activities and mass in cardiac diseases
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摘要: 目的: 肌酸激酶同工酶(CK-MB)质量和活性在疾病诊断中的应用。方法: 患有心血管类疾病和非心血管类疾病的患者以心肌钙蛋白(card iac tropon in T,cTnT)表达阳性、阴性分组。结果: 非心血管疾病组CK-MB活性结果异常与质量异常无明显相关(P>0.05)。心血管疾病组cTnT>0.1,质量和活性的结果异常明显相关(P<0.05);cTnT<0.1组,CK-MB质量与活性结果异常也具有相关性,且CK-MB活性略高于正常参考值,CK-MB质量均数在参考值范围内。结论: CK-MB质量和活性在心脏类疾病的诊断中都很敏感,CK-MB质量对于因素干扰稳定性好于活性的测定。Abstract: Objective:To investigate the usefulness of CK-MB activities and CK-MB mass in cardiac diseases or non-cardiac diseases.Methords:Patients with or without cardiac diseases were divided into cardiac troponin T（cTnT）negative（cTnT-） or cTnT positive（cTnT+） group. Results:in non-cardiac diseases group,there was no correlation between CK-MB and CK-MB mass（P＞0.05）,while in cardiac diseases group,CK-MB was correlated with CK-MB mass when TnT＞0.1（P＜0.01）and TnT＜0.1（P＜0.05）.Conclusion:There were both well sensitiveity to cardiac diseases on CK-MB mass and CK-MB activities;while CK-MB mass has better stability than CK-MB activities to different conditions.
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