Abstract: Objective:Analysing detectable rates，drug resistance and application of cefpiramide in the elder patients with stenotrophomonas maltophilia pneumonia.Methods：Analysing 222strains bacteria of sputum culture in the 187 elder patients with pneumonia；62 strains drug sensitivity of stenotrophomonas maltophilia；application values of cefpiramide in the 18cases elder patients with stenotrophomonas maltophilia pneumonia.Results：Detectable rates of stenotrophomonas maltophilia was number five in the 222strainas becteria of sputum culture in the 187elder patients with pneumonia；stenotrophomonas maltophilia was drug resistance for most antibiotics；100% resistance rates were ampicillin，cefazolin，aztreonam，cefuroxine，impenem，tetracycline，nitrofurantion. cefotaxime sodimm was 95.92% drug resistance；gentamicin was 84.91%；pipercillin was 76%；amikcin was 74.58%；cefoperazone sodium was 67.65%；ciprofloxacin was 61.70%；ticarcillin was 60%；timentin was 60% drug resistance.Effective rates was 66.67% and bacterial clearance rates was 77.78% in the 18elder patients with stenotrophmonas maltophilia pneumonia for cefpriramide treatments.Conclusion：Detectable rates of stenotrophomonas maltophilia was number five in the 222strains bacteria of sputum culture in the 187elder patients with pneumonia；stemotrophomonas maltophilia was drug resistance for most antibiotics；Effective rates was 66.67% and bacterial clearance rates was 77.78% in the 18elder patients with stenotrophomonas maltophilia pneumonia for cefpiramide.