复方紫归对烫伤大鼠肠道免疫功能的影响

Effect of Zigui granule on intestinal immunobarrier in rat after scald

摘要: 目的：研究ZG对烧伤后肠道免疫功能的调节。方法：40%体表面积（TBSA）Ⅲ度烫伤大鼠灌喂复方紫归（ZG）3g/kg，2/d，共3d（ZG组），灌喂0.9%生理盐水8ml/kg，2/d，共3d（对照组）。结果：ZG组肠道内容物IgA含量明显高于对照组（P＜0.05）；ZG组肠固有层CD3＋T淋巴细胞活性明显增强（P＜0.05）；ZG组血浆LPS、MDA明显低于对照组（P＜0.05）。结论：复方紫归对烫伤大鼠肠道免疫功能有一定的保护作用，可减轻肠道缺血再灌注损伤和肠源性内毒素血症。

Abstract: Objective: In ordr to protect the intestinal immunobarrier, Zigui granule （ZG） a complex of Chinese herbs was used to treat the burned rats.Methods:The burned rats were randomly divided into two groups:（1）ZG treated group feded with ZG: （2）control group: feded with 0.9% salime. Results:The levels of IgA in the intestinal content and the number of CD3 T lymphocytes in the lamina propria of the ZG groups were significantly increase （P＜0.05）, and the levels of plasma MDA and LPS were significantly lower than those of the control group （P＜0.05）.Conclusion:The results indicate that ZG may protect the inteastinal immunobarrier and prevent gut-derived endotoxemia after burn injury.