Abstract: Objective:To study the clinicopathologic features and prognosis of the patients with early gastric cancer（EGC）.Methods: 308 patients with one lesion treated surgically for EGC from 1983 to 2005 were analyzed retrospectively.245 patients were followed up.Results: The positive rate of double-contrast barium upper gastrointestinal radiography was 70.1%.The positive rate of fecal occult blood test was 5.8%.The combined positive rate of serum CEA,CA199,CA724,CA153 and CA125 was 10.5%.The rate of lymph node metastasis was 9.9%.The 5-year survival rate was 92.23%.Cox multivariate analysis showed that submucosal invasion was a positive independent risk factor and paracarcinomatous mucosal middle-severe atrophy was a independent protective factor for survival.There were 5.3% EGC patients with metachronous other primary carcinomas after gastrectomy.Conclusion: Gastroscopy is still the most effective method to find EGC.The survival rate with submucosal invasion is lower and that of EGC with paracarcinomatous mucosal middle-severe atrophy is higher.Postoperatively we must be careful of metachronous multiple primary cancer.