原发性膀胱恶性淋巴瘤

Primary malignant lymphoma of the bladder

  • 摘要: 目的: 提高对原发性膀胱恶性淋巴瘤的早期诊断。方法: 通过免疫组化方法对4例原发性膀胱恶性淋巴瘤进行病理分型,并对其临床表现、诊断、治疗及预后进行讨论。结果: 临床主要表现:血尿、排尿困难、尿频。膀胱镜检查可见片状或半球形规则或不规则突起,表面粘膜常光滑。4例经免疫组化检查均为B细胞淋巴瘤,其中低度恶性粘膜相关淋巴瘤3例(CD20+/CD10-/CD5-),滤泡中心细胞淋巴瘤1例(CD20+/CD10+)。4例患者存活期为37年。结论: 膀胱恶性淋巴瘤主要为B细胞型,且以低度恶性粘膜相关淋巴瘤多见。膀胱镜检查粘膜大多光滑,隆起不明显时容易漏诊。明确诊断依靠病理活检,治疗采用手术切除,辅以放化疗,大部分患者预后好。

     

    Abstract: Objective: To improve the early diagnosis of primary malignant lymphoma of the urinary bladder. Methods: 4 cases of primary malignant lymphoma of the urinary bladder were immunohistochemically analysed for the phenotype and the clinical presentations、treatment and prognosis were also discussed. Results: The most common symptom is haematuria、dysuria and frequency. Cystoscopic examination showed the tumor as pachy or hemisphered protrudings but the mucosa was usually intact. Immunohistochemically the tumors all showed B cell phenotype, including three as low grade mucosa-associated lymphoid tissue lyphoma(CD20+/CD10-/CD5-) and one as follicular center cell lyphoma(CD20+/CD10+). The survival of patient rang from 3~7 years. Conclusion: malignant lymphoma of urinary bladder were predominantly B cell type and most of them were low grade mucosa-associated lymphoid tissue lymphoma. Diagnosis was established by histological examination. The treatment of the patients include Surgical resection with or without radiotherapy and chemotherapy. The prognosis was thought to be favorable.

     

/

返回文章
返回