肝硬化患者纤溶活性变化与临床指征关系的探讨
To investigate the relationship between fibrinolysis and clinical parameters in patients with different degrees of hepatocirrhosis
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摘要: 目的: 探讨肝硬化患者纤溶活性增高与组织纤溶酶原激活物(t-PA),组织纤溶酶原激活物抑制剂(PAI)的关系。方法: 根据Ch ild-Pugh分级把明确诊断为肝硬化的86例患者分为三级,A级26例,B级30例,C级30例。对每例样本检测组织纤溶酶原激活物(t-PA)抗原,组织纤溶液酶原激活物抑制剂(PAI),纤维蛋白(原)降解产物(FDP)和D-二聚体(D-d im er)。结果: 46例具有正常纤溶活性(FDP<5 mg/l;D-d im er<0.5 mg/l)的病例,其中A级26例,B级12例,C级8例,t-PA抗原随病情严重程度而显著性升高(P<0.05),而PAI活性在三组结果近似(P>0.05)。t-PA在纤溶活性高的患者略高于正常纤溶患者,但差异没有显著性意义(P>0.05);PAI在两组间结果近似,差异没有显著性意义(P>0.05)。结论: t-PA随病情加重而显著性升高,PAI随病情加重变化不大。Abstract: Objective: To Investigate the relationship between hyperfibrionlysis and tissue plasminogen activator antigen（t-PA）,plasminogen activator inhibitor activity（PAI） in patients with different degrees of hepatocirrhosis associated with viral hepatitis.Methods: Eighty-six patients with cirrhosis were divided into three subgroups（A,B,and C） on the basis of Child-Pugh classification.Tissue plasminogen activator antigen（t-PA）,plasminogen activator inhibitor activity（PAI）,fibrin/fibrinogen degradation products（FDP）,and fragment D-dimer were measured in each patients.Results: t-PA antigen was incresed with the grade of cirrhosis in hyperfibrinolysis patient（P＜0.05）.t-PA and PAI activity had no significant changes in patients between hyperfibrionlysis and normal fibrionlysis.Conclusion: t-PA is a important biomarker in cirrhosis patient with hyperfibronlysis to estimate the grade of cirrhosis.
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