老年多原发癌早期诊断与治疗

Early diagnosis and treatment of multiple primary malignant tumors in the elderly

  • 摘要: 目的:总结多原发癌的早期诊断经验,探讨综合治疗方法。方法:回顾22年间诊断老年多原发癌70例临床病理资料,男68例,女2例,发病年龄从60到90岁。双重癌52例,三原发癌18例。结果:首癌早期诊断45例,次癌早期诊断50例,第三癌早期诊断14例,双原发癌早期诊断26例,三原发癌早期诊断9例。13例腔内早期肿瘤经内镜治疗,达无病生存,中位数60个月;诊断末癌后5年以上45例,5年生存35.5%(16/45));死亡46例,非肿瘤事件20例(占43.47%)。结论:临床症状无助早期诊断,肿瘤标志物、影像学检查是发现早期肿瘤的重要手段。心脑血管、呼吸、消化道疾病是影响老年多发癌患者生存时间的重要因素。

     

    Abstract: Objective: Experience of diagnosis for multiple primary malignant tumors(MPMTs) in early stage was summarized in order to give proper treatment in the elderly Methods: Seventy cases of MPMTs patients aged from 60 to 90 year old admitted to our hospital in the period of 1980 to 2002 were ananlyzed retrospectively There were 68 males and 2 femels fifty two cases of them had double primary malignant tumors and 18 cases had triple primary malignant tumors Results: Forty five cases,50 cases and 14 cases of them in the first, second and third primary malignant cancer were dignosed in early stage respectively There were 26 cases with double carcinoma and nine cases with triple cacer in the early stage thirteen cases with gastric carcinoma and bladder in early staging cancer were treated by endoscopic resection, of which median servival rate without cancer were 60 months(range,6 to 120 months) The 5-year survival rate for patients with MPMTs was 35 5% Twenty of forty six deaths were not directly tumor related Conclusion: Clinical symptem is not helpful for diagnosis of cancer in early stage Tumor marks, endoscopy and BUS were important procedure for early diagnoses of MPMTs Causes included sudden death, respiratory failure and upper gastrointestinal tract bleeding affect the 5-year servival rate of the patients with M PMTs

     

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