一氧化氮供体SIN-1对烧伤大鼠内脏血液供给的影响

The protective effects of SIN-1, a kind of nitric oxide donor, on visceral blood supply in burnt rats

摘要: 目的：了解外源性补充NO对烧伤后内脏血液供给的影响。方法：以大鼠30%Ⅲ度烧伤为模型，观察补充NO载体SIN-1后烧伤大鼠肝、肾血流量、动脉血气分析及内脏含水量的变化。结果：大鼠烧伤后动脉血pH、PaO₂下降，PaCO₂升高，肝、肾脏血流量明显减少，心、肝、肺、肾4种脏器含水量持续增加，伤后及早静脉输注SIN-1可明显改善上述指标。结论：烧伤后由于内源性NO的相对不足，导致内脏血管收缩，造成组织缺血缺氧，外源性补充NO则可一定程度逆转烧伤后内脏血供不足

Abstract: Objective: To evaluate the effects of exogenous NO supplement on visceral blood supply postburn.Methods: By use of a 30% TBSA Ⅲ degree burnt rat model, we observed the changes of renal or hepatic blood flow, artery blood analysis, visceral water contents after the supplement of SIN-1, a kind of nitric oxide donor. Results: There was obvious deficiency of blood supply in viscera postburn. Administration of SIN-1, without affecting the arterial blood pressure, could revert the decrease of pH, PaO₂, renal or hepatic blood flow to some extent reduce the water contents of heart, liver, lung, kidney postburn. Conclusion: The relative deficiency of nitric oxide in the early stage postburn in rat contribute to the decrease of blood suupply in viscera.