Abstract: Objective To study the clinical effect of Staphylococcal protein A （SPA） immunoadsorption in renal transplant recipients with high panel reactive （anti HLA） antibodies. Methods Five renal transplant recipients with high anti HLA antibodies were treated 21 times with immunoadsorption column （Wuhan Paisheng）, and then underwent kidney transplantation. Results The levels of serum panel reactive antibody （PRA）, IgG and IgM were significantly decreased in 4 renal transplant recipients with high panel reactive （anti HLA） antibodies after treatment, with no acute or hyper-acute rejection occurred. Acute rejection occurred in 1 renal transplant recipient with a high PRA level. However, the serum levels of PRA and immunoglobin were remarkably reduced and acute rejection was alleviated in this patient after treatment. Conclusion Protein A immunoadsorption can effectively decrease the high serum PRA level in renal transplant recipients, and can thus be used in prevention and treatment of rejection after kidney transplantation.