急性胰腺炎患者血清细胞因子和炎症介质的变化
Alteration of cytokines and inflammatory mediators in the serum of acute pancreatifis patient
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摘要: 目的: 探讨急性胰腺炎(AP)患者血清C反应蛋白(CRP)白介素-10(IL-10),肿瘤坏死因子-α(TNF-α),一氧化氮(NO)的临床意义。方法: 分为三组,轻型AP(MAP)组,重型AP(SAP)组和对照组,同时测定上述指标。结果: ①AP患者血清CRP、IL-10、TNF-α、水平均明显高于对照组(P<0.01),血清NO水平均明显低于正常对照组(P<0.01)。②SAP患者血清CRP,TNF-α,水平均明显高于MAP组(P<0.01)③MAP组患者血清IL-10、NO水平均明显高于SAP组(P<0.01)。结论: 上述血清因子有助于AP的诊断和其病情严重程度的识别。Abstract: Objective: To study the relations between serum levels of CRP,IL-10,TNF-α and NO in patients with acute pancreatitis（AP）,and their clinical significance. Methods: Contained moderate acute pancreatitis（MAP）,severe acute pancreatitis（SAP） and contrast group.Specimens were examined the serum levels of CRP,IL-10,TNF-α. Results: （1）The serum levels of CRP,IL-10,TNF-α in AP group were more than that in contrast group（P＜0.01）,the serum levels of ON in AP group were less than that in contrast group（P＜0.01）.（2）The serum levels of CRP,TNF-α,in SAP group were more than that in MAP（（P＜0.01））.（3）The serum levels of IL-10,NO in MAP group were more than that in SAP（P＜0.01）. Conclusions: The results show that all those levels have directive dinical singnificances to judge serious degrees of AP.
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