Abstract: Objective To compare the effects of endoscopic treatment on esophageal papilloma. Methods Forty-five patients with esophageal papilloma were treated in our hospital with microwave（MV）and argon-beam coagulator（ABC）.After 3-6 months,the patients underwent gastroscopy,and their clinical manifestations were recorded and advantages of the two treatment modalities were compared. Results The curative rate of microwave treatment for 15 patients and argon-beam coagulator treatment for 30 patients was 86.70%and 93.30%,respectively（χ2=0.03,P＞0.05）.The improvement rate of clinical manifestations was 86.70%:in 15 patients after microwave treatment and 96.70%in 30 patients after argon-beam coagulator treatment（χ2=0.40,P＞0.05）,respectively. Conclusion The curative effect of treatment with endoscopic microwave and argon-beam coagulator on esophageal papilloma is almost similar.