Abstract: Objective To observe the therapeutic effect of sodium hyaluronate（HA）injected into knee joint cavity through the femoral quadriceps muscle tendon on knee osteoarthritis. Methods Forty-eight knee osteoarthritis patients（70 knees）were injected with HA through the femoral quadriceps muscle tendon at the superior border of patella.Their clinical symptoms were scored with HSS before and 1 month after injection of HA. Results HA was successfully injected through the femoral quadriceps muscle tendon.The HSS score for the clinical symptoms of patients was significantly higher after HA injection than before HA injection with a significant difference in pain relief and function improvement（P＜0.01）. Conclusion Injection of HA into knee joint cavity through the femoral quadriceps muscle tendon is a simple and easy to manipulate therapy which can improve the clinical symptoms of knee osteoarthritis patients with a high success rate and less sufferings.