Abstract:
Objective To investigate the biodistribution of
11C-podophyllotoxin （
11C-PDT） in a murine model of lung carcinoma.
Methods Mice bearing lung carcinoma were randomly divided into three groups according to the injection time of
11C-PDT. Biodistribution of
11C-PDT in mice was detected with a well-gamma detector 15, 30, and 60min after
11C-PDT injection from the tail vein.
Results The distribution of
11C-PDT radioactivity was the highest in kidneys. A considerable radioactive uptake was observed in the tumor. However, the tumor/muscle ratio was rather high 60min after
11C-PDT injection.
Conclusion 11C-PDT can be used as a promising PET tracer for lung carcinoma.
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