203例鼻咽癌的预后与死亡因素分析

Analysis of the Prognosis and the Causes of Death in 203 Cases with Nasopharyngeal Carcinoma

  • 摘要: 1981年至1992年收治鼻咽癌203例,男160例,女43例,平均年龄47岁。Ⅰ期7例,ⅡI期84例,Ⅲ期72例,Ⅳa期34例,Ⅵb期6例。总的5年生存率为51.4%(72/140)。各期5年生存率:Ⅰ期100%,Ⅱ期76.2%,Ⅲ期36.6%,Ⅳa期16%,Ⅳ6期0。血行转移为主要死亡原因,占死亡病例81%(42/52)。颈部淋巴结转移程度与血行转移有直接关系,N3组血行转移率高达86.9%(20/23),应联合应用化疗以降低血行转移率。治疗后鼻咽部局部复发率为21.8%(38/174),第二程放疗局部控制率为28.9%(11/38)。

     

    Abstract: Between 1981 to 1992 we treated 203 patients ( 160 males and 43 female, mean age 47 years) with nasopharyngeal carcinoma by radiotherapy. Stage distribution were Ⅰ 7,Ⅱ 84,Ⅲ72, Ⅳ a 34, and Ⅳb 6. The actuarial five year survivat rate of all patients were 51.4%(72/140), for stage Ⅰ it was 100% and stage Ⅱ 76.2%, stage Ⅲ36.6%, stage Ⅳa 16%, and none was survival for the patients of stage Ⅳb, The main cause of death was hematogenous metastasis(81%, 42/52). The staus of cervical lymphonode metastasis was related with blood spreading.The rate of blood spreading for group N3 was 86.9%(20/23). The combined treatment with chemotherapy could decrease the hematogenous metastasis rate. The local recurrence after treatment was 2l. 8%(38/174), and the local control rate for the second course of treatment was 28.9%(11/38).

     

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