糖耐量减低合并冠状动脉粥样硬化性心脏病患者冠脉病变特点
Clinical and coronary angiographic features in CHD patients with impaired glucose tolerance
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摘要: 目的:研究糖耐量减低(IGT)合并冠心病患者冠脉病变的特点。方法:163例明确诊断冠心病患者,行口服葡萄糖耐量试验,合并糖耐量减低59例,正常糖代谢40例,检测两组BMI、腰围、血糖、血压、血脂等,冠脉造影比较两组冠状动脉病变情况。结果:与NGT组相比,IGT组存在体重指数、腰围及血脂明显异常。冠脉造影结果显示,IGT组与NGT组相比较,双支以上病变明显增多,具有显著统计学意义(P<0.05);在受累血管方面,左前降支(LAD)、左回旋支(LCX)、右冠状动脉(RCA)、左主干(LM)均可受累,两组均以LAD为主;就血管狭窄程度而言,IGT组与NGT组相比,血管狭窄程度大于75%明显增多,具有统计学意义(P<0.05)。结论:糖耐量减低合并冠心病时,腰围、体重指数增加,血脂异常明显,血管病变以多支病变为著,且血管狭窄程度严重。Abstract: Objective:To investigate the clinical and coronary angiographic features in CHD patients with impaired glucose tolerance.Methods: A total of 163 cases with coronary heart disease were performed 75g OGTT,and 59 cases were diagnosed as IGT,40 cases were normal glucose.The clinical features including height,weight,BMI,waist circumference,blood pressure,plasma lipids were investigated,and the coronary features were obtained through coronary angiography.Results: BMI and WC are higher in IGT group（P＜0.05）.TG,TC and LDL-C are higher in IGT group（P＜0.05） and HDL-C is lower in IGT group（P＜0.05）.The result of coronary angiography showed that the coronary multivessel changes and the severity of coronary artery stenosis were more frequent in IGT group than in control group as to the extent of stenosis,more than in IGT group.Conclusion: Obesity and blood lipids disorder are found more seriously in patients with impaired glucose tolerance combined with coronary heart disease.and impaired glucose tolerance is related to the severity of coronary artery lesions.
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