东南沿海某部皮肤真菌病流行病学调查及药敏试验
Epidemiology of dermatomycoses and susceptibility test in a troops of the south-east China
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摘要: 目的: 摸清该地区部队皮肤真菌病发病情况及菌种分布,筛选出高效、经济、实用的外用抗真菌药物。方法: 对选定部队进行皮肤真菌病流行病学调查,采集标本,用改良KANE/FISCHER皮肤癣菌鉴定系统对采集的标本进行菌种分离和鉴定,并依据NCCLS2003年版M38-A方案对所分离菌种进行药敏试验。结果: 该部队皮肤真菌病发病率为29.80%,其中足癣占75.31%,菌种主要为红色毛癣菌(73.30%)和须癣毛癣菌(21.21%)。所选8种药物对受试真菌均有较好的敏感性。结论: 该部队皮肤真菌病发病率高,红色毛癣菌为主要致病菌,8种药物的MIC之间的差异有显著性,特比奈芬、布替奈芬为较适宜的药物。Abstract: Objective: To identify the etiological and epidemiological factors of dermatophyte infections in the South-East China, to filtrate suitable drugs in the troops. Methods: Use improved KANE/FISCHER system to identify the dermatophyte.To determine the Minimum Inhibitory Concentration （MIC） with the National Committee for Clinical Laboratory Standards （NCCLS） approved standard broth microdilution method （M38-A）. Results: The prevalence of dermatomycoses was 29.80%. tinea pedis was the most（75.31%）. Trichophyton rubrum was the most frequent dermatophyte. All the 8 kinds of drugs were sensitive to the isolates. Conclusions: Trichophyton rubrum was the most frequent dermatophyte. There were significant differences among these 8 kinds of drugs. Terbinafine and Butenafine was the suitable drugs
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