Abstract: Objective To study the feasibility of radiacal operation for lung cancer accompanying severe coronary stenosis 3 weeks after coronary stent implantation. Methods Ten patients with lung cancer accompanying severe coronary stenosis who underwent lobectomy 3 weeks after coronary stent implantation in our hospital from December 2008 to December 2010 were reviewed.Their clinical data were compared with those about the patients who underwent routine small incision lobectomy. Results Of the 27 stents implanted in the 10 patients,10,9 and 8 were Cypher,Firebird and Partner stents,respectively.Thirteen stents were distributed in the left anterior descending vessel,5 in the left circumflex branch,and 6 in right coronary artery.The surgical success rate was 100% with the stenosis decreased from 80%-100% before operation to 5% after operation.Of the 10 patients who underwent operation,1 received right upper lobectomy,2 right middle and lower lobectomy,1 right lower lobectomy,5 left upper lobectomy,and 1 left lower lobectomy.The procedure was successful for all patients,and postoperative pathology proved that the tumor was malignant.No significant difference was observed in operation time,blood loss,and postoperative hospital stay time between different groups.The chest drainage time was slightly longer in operation group than in control group,but no bleeding occurred in operation group. Conclusion Pulmonary lobectomy is safe procedure for pulmonary carcinoma shortly after coronary stent implantation when anticoagulants are rationally used and perioperaton is well prepared.If the condition of lung cancer patients is allowed,hybrid surgery can be considered.