长期服用小剂量阿司匹林对老年人大肠息肉生长的影响

Effect of low-dose aspirin use on large intestine polyps in elderly

摘要: 目的: 了解老年人使用小剂量阿司匹林对大肠息肉生长的影响。方法: 回顾性分析52例长期服用小剂量阿司匹林的老年人服用前后结肠镜检查结果,并与63例未服用阿司匹林的老年人进行对照分析。结果: 服用小剂量阿司匹林4～ 6年大肠息肉年负荷明显低于服用前(1.3± 1.8)对(2.9± 5.2) mm/year,P<0.05,服用时间≤ 2年(2.6± 6.6) mm/year、2年<服用时间≤ 4年(2.0± 3.8) mm/year大肠息肉年负荷与服用前比较无显著性差异(P>0.05)。结论: 老年人服用小剂量阿司匹林远期可抑制大肠息肉生长。

Abstract: Objective: To investigate effect of low-dose aspirin use on large intestine polyps in elderly. Methods: 52 subjects using low-dose aspirin and 63 controls were analyzed retrospectively according to colonoscopy examination results. Results: Large intestine polyp burden per year in subjects using low-dose aspirin for 4～6 years was lower significantly than that in subjects before using aspirin （1.3±1.8）vs（2.9±5.2）mm per year, P ＜0.05 .The polyp burden after using aspirin for 0～2 years （2.6±6.6）mm per yearand 2～4 years（2.0±3.8）mm per year was not different in comparison with that before using aspirin respectively（P ＞0.05）. Conclusions: Long-term low-dose aspirin use in elderly can inhibit growth of large intestine polyps.