Abstract: Objective: To investigate the quantity of five kinds of antomicrobial agnets priscribed yearly from 1994 to 2003 and the resistance of Pseudomonas aerugonosa,and analyze the correlation between them. Methods: Susceptibility test to antimicrobial agnets was performed by disk diffusion method and analysed by WHONE 5.3.The correlation between DDDS and the resistance were analyzed using statistics. Results: The percentage of resistance of Pseudomonsa aeruginosa to the five drugs increased with years.The increase of resistance was more than 12.5% for each antimicrobial agent compared result from 1994 with that from 2003.The analysis revealed a significant positive correlation between the resistance and DDDS of imipenem and ciprofloxacin.The consumption of imipenem and ciprofloxacin is also related to the resisitance of Pseudomonsa aeruginosa to piperacillin. Conclusion: The correlation between the use of imipenem and ciprofloxacin and their resistance in Pseudomonsa aeruginosa strains,also revealed an association between imipenem and ciprofloxacin consumption and resistance to piperacillin.