Abstract: Objective: Chronic heart and renal failure are closely related in terms of pathophysiology When heart failure is complicated with renal failure,it is difficult to control clinically The purpose of this study is to observe the effect of PGE1 on chronic heart and renal failure Methods: The effects of PGE1 on hemodynamics and renal biochemical parameters were observed in 14 patients with heart and renal dysfunction by using Swan Ganze catheter and renal biochemical examination Results: SVRI,CO were improved markedly （P＜0.005）and explored dose response and phaes response cures after intervenuse PGE 1 Marked shifts were not found in HR*BP Declined LVSWI enhanced markedly （P＜0.005） All Parameters such as serum BUN,Cr,and urinary quantity were improved markedly （P＜0.005 respectively） except NAG and urine protein Medium molecular urine protein decreased （P＜0.005） Marked relationship between improving rate of U/B Cr and that of SVR （r=-0.9） and CO （r=0.7） was found Conclusions: Cardiac output and renal function could be improved and systolic pressure and resistance be declined in patients with heart and renal dysfunction The improvement of renal function related with that of hemodynamics in the aspect of U/B Cr elevating rate and SVR-CO improving rate