Abstract: Erythrocyte ATP level in pathients with chronic renal failure was found to be significantly higher than that in normal control.There was a negative correlation between the erythrocyte ATP contents and membrane ATP ase activity,and a positive correlation between the erythrocytes ATP contents and serum creatinine or urea nitrogen.High concentration of ATP may be resulted from:1.impeded ATP utilization,2.strenghtened reversion of pump;3.increased uptake and conversion of adenosine.The Increased level of ATP in patients with CRF may be a compensatoey regulation of energy metabolism and advantageous to the patients.